2017년08월21일mon
로그인 | 회원가입
OFF
트위터로 보내기 싸이월드 공감
기사글확대 기사글축소 기사스크랩 이메일문의 프린트하기
인체 골수 유래 줄기세포배양액의 주름 완화 효과
중앙대학교병원 피부과 김범준 교수 연구팀(권태린, 오창택, 최은자 연구원)
[ 2015년 12월 14일 09시 58분 ]

Background

 

Mesenchymal stem cells(MSCs) are promising therapeutic agents for various diseases.

 

Aims

 

To investigate the effects of conditioned medium from human bone marrow derived mesenchymal stem cells (MSC-CdM) on pro-collagen production and wirnkle formation, we performed in vitro and in vivo experiments.

 

Methods

 

We assessed the effects of MSC-CdM on proliferation and photo-aging in human dermal fibroblasts after UVB exposure using enzyme activity assays for collagen type1 secretion and MMP-1. To determine the effect of topically applied MSC-CdM on wrinkle formation, MSC-CdM (1% and 10%) and vehicle (propylene glycol: ethanol, 7:3) were applied to the dorsal skin of UVB-irradiated hairless mice for 8weeks.

 

We examined the effects on wrinkle formation by assessing visual skin grading, replica, tape stripping, transepidermal water loss (TEWL), and skin hydration measurement. We also examined histology of the lesions using hematoxylin-eosin, Masson's trichrome, and immunohistochemical staining.

 

Results

 

MSC-CdM markedly reduced UV-induced matrix metalloproteinase-1 expression and increased pro-collagen synthesis in a dose-dependent manner. Our findings suggest that MSC_CdM induces repair of dermal damage and dffacement of wrinkles on UVB-irradiated hairless mice through protective effect of hydration.

 

Conclusion

 

These results support an anti-wrinkle effect of MSC-CdM that involves increased collagen synthesis and suggest that MSC-CdM might be a potential candidate for preventing UV-induced skin damage.

대기뉴스이거나 송고가 되지 않도록 설정됨
데일리메디 webmaster@dailymedi.com
이기자의 다른뉴스보기
무통장입금 정보입력 입금자명 입금예정일자
(입금하실 입금자명 + 입금예정일자를 입력하세요)
[관련뉴스]
- 관련뉴스가 없습니다.
트위터로 보내기 싸이월드 공감
기사글확대 기사글축소 기사스크랩 이메일문의 프린트하기
웹기반 고위험음주 개입 플랫폼의 개발과 효과성 연구 (2016-04-18 09:52:21)
헬리코박터 파일로리 검사: 어디서, 어떻게 (2015-09-21 09:44:43)